Thioproperazine Dimethanesulfonate may be available in the countries listed below.
Thioproperazine Dimethanesulfonate (JAN) is also known as Thioproperazine (Rec.INN)
International Drug Name Search
Glossary
| JAN | Japanese Accepted Name |
| Rec.INN | Recommended International Nonproprietary Name (World Health Organization) |
In the US, Family Meltus Chesty Coughs is a member of the drug class expectorants and is used to treat Bronchitis and Cough.
UK matches:
Guaifenesin is reported as an ingredient of Family Meltus Chesty Coughs in the following countries:
International Drug Name Search
Glossary
| SPC | Summary of Product Characteristics (UK) |
Fenat may be available in the countries listed below.
Ketotifen fumarate (a derivative of Ketotifen) is reported as an ingredient of Fenat in the following countries:
International Drug Name Search
Metronidazol Baxter may be available in the countries listed below.
Metronidazole is reported as an ingredient of Metronidazol Baxter in the following countries:
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In some countries, this medicine may only be approved for veterinary use.
Bacitracin methylene disalicylate (a derivative of Bacitracin) is reported as an ingredient of Bacitracin MD in the following countries:
Monensin is reported as an ingredient of Bacitracin MD in the following countries:
Monensin sodium salt (a derivative of Monensin) is reported as an ingredient of Bacitracin MD in the following countries:
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Taquidine may be available in the countries listed below.
Lansoprazole is reported as an ingredient of Taquidine in the following countries:
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Robatrol may be available in the countries listed below.
Ribavirin is reported as an ingredient of Robatrol in the following countries:
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Rec.INN
P01BA06
0000086-42-0
C20-H22-Cl-N3-O
355
Antiprotozoal agent: Antimalarial
Phenol, 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-
International Drug Name Search
Glossary
| BAN | British Approved Name |
| BANM | British Approved Name (Modified) |
| DCF | Dénomination Commune Française |
| IS | Inofficial Synonym |
| OS | Official Synonym |
| PH | Pharmacopoeia Name |
| Rec.INN | Recommended International Nonproprietary Name (World Health Organization) |
Losartan/Hydrochlorothiazide Teva may be available in the countries listed below.
Hydrochlorothiazide is reported as an ingredient of Losartan/Hydrochlorothiazide Teva in the following countries:
Losartan potassium salt (a derivative of Losartan) is reported as an ingredient of Losartan/Hydrochlorothiazide Teva in the following countries:
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Piridoksina hidrohlorids may be available in the countries listed below.
Pyridoxine hydrochloride (a derivative of Pyridoxine) is reported as an ingredient of Piridoksina hidrohlorids in the following countries:
International Drug Name Search
Fosinopril/HCT Interpharm may be available in the countries listed below.
Fosinopril sodium salt (a derivative of Fosinopril) is reported as an ingredient of Fosinopril/HCT Interpharm in the following countries:
Hydrochlorothiazide is reported as an ingredient of Fosinopril/HCT Interpharm in the following countries:
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Topiegis may be available in the countries listed below.
Topiramate is reported as an ingredient of Topiegis in the following countries:
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Triazine may be available in the countries listed below.
Cyclizine hydrochloride (a derivative of Cyclizine) is reported as an ingredient of Triazine in the following countries:
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Epithra may be available in the countries listed below.
Epirubicin hydrochloride (a derivative of Epirubicin) is reported as an ingredient of Epithra in the following countries:
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Tacron may be available in the countries listed below.
Naproxen is reported as an ingredient of Tacron in the following countries:
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Acido Alendronico Semanal Ranbaxy may be available in the countries listed below.
Alendronic Acid sodium trihydrate (a derivative of Alendronic Acid) is reported as an ingredient of Acido Alendronico Semanal Ranbaxy in the following countries:
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Gabapentin ABC may be available in the countries listed below.
Gabapentin is reported as an ingredient of Gabapentin ABC in the following countries:
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Akinspray may be available in the countries listed below.
Benzalkonium chloride (a derivative of Benzalkonium) is reported as an ingredient of Akinspray in the following countries:
Lidocaine hydrochloride (a derivative of Lidocaine) is reported as an ingredient of Akinspray in the following countries:
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Isotretinoin-ratiopharm may be available in the countries listed below.
Isotretinoin is reported as an ingredient of Isotretinoin-ratiopharm in the following countries:
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Colimicina may be available in the countries listed below.
Colistin sulfate (a derivative of Colistin) is reported as an ingredient of Colimicina in the following countries:
Colistin sulphomethate sodium (a derivative of Colistin) is reported as an ingredient of Colimicina in the following countries:
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Amigdazol NF may be available in the countries listed below.
Benzydamine is reported as an ingredient of Amigdazol NF in the following countries:
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Aminophyllinum Retard may be available in the countries listed below.
Aminophylline is reported as an ingredient of Aminophyllinum Retard in the following countries:
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Freshen Bisacodyl Laxative may be available in the countries listed below.
Bisacodyl is reported as an ingredient of Freshen Bisacodyl Laxative in the following countries:
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Cefacin-M may be available in the countries listed below.
Cefalexin is reported as an ingredient of Cefacin-M in the following countries:
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Lidocaine Grindeks may be available in the countries listed below.
Lidocaine hydrochloride (a derivative of Lidocaine) is reported as an ingredient of Lidocaine Grindeks in the following countries:
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Excef may be available in the countries listed below.
Cefixime is reported as an ingredient of Excef in the following countries:
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Aspen Acyclovir may be available in the countries listed below.
Aciclovir is reported as an ingredient of Aspen Acyclovir in the following countries:
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Repaglid may be available in the countries listed below.
Repaglinide is reported as an ingredient of Repaglid in the following countries:
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Micosten may be available in the countries listed below.
Clotrimazole is reported as an ingredient of Micosten in the following countries:
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Biperideno Rospaw may be available in the countries listed below.
Biperiden hydrochloride (a derivative of Biperiden) is reported as an ingredient of Biperideno Rospaw in the following countries:
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In the US, Benzamycin (benzoyl peroxide/erythromycin topical) is a member of the drug class topical acne agents and is used to treat Acne.
US matches:
Benzoyl Peroxide is reported as an ingredient of Benzamycin in the following countries:
Erythromycin is reported as an ingredient of Benzamycin in the following countries:
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Ceredist may be available in the countries listed below.
Taltirelin hydrate (a derivative of Taltirelin) is reported as an ingredient of Ceredist in the following countries:
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Pheniramin may be available in the countries listed below.
Chlorphenamine maleate (a derivative of Chlorphenamine) is reported as an ingredient of Pheniramin in the following countries:
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Artrocaptin may be available in the countries listed below.
Tolmetin sodium salt (a derivative of Tolmetin) is reported as an ingredient of Artrocaptin in the following countries:
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In some countries, this medicine may only be approved for veterinary use.
Lincomycin hydrochloride monohydrate (a derivative of Lincomycin) is reported as an ingredient of Lincomycin Spectinomycin in the following countries:
Spectinomycin dihydrochloride (a derivative of Spectinomycin) is reported as an ingredient of Lincomycin Spectinomycin in the following countries:
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Lanato C may be available in the countries listed below.
Lanatoside C is reported as an ingredient of Lanato C in the following countries:
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Ticlopidina-ratiopharm may be available in the countries listed below.
Ticlopidine hydrochloride (a derivative of Ticlopidine) is reported as an ingredient of Ticlopidina-ratiopharm in the following countries:
International Drug Name Search
In the US, Cisplatin (cisplatin systemic) is a member of the drug class alkylating agents and is used to treat Bladder Cancer, Blood Cell Transplantation, Bone Marrow Transplantation, Brain Tumor, Cervical Cancer, Neuroblastoma, Non-Small Cell Lung Cancer, Osteogenic Sarcoma, Ovarian Cancer and Testicular Cancer.
US matches:
UK matches:
Cisplatin (BAN, JAN, USAN) is known as Cisplatin in the US.
Colestipol hydrochloride (a derivative of Colestipol) is reported as an ingredient of Cisplatin in the following countries:
International Drug Name Search
Glossary
| BAN | British Approved Name |
| JAN | Japanese Accepted Name |
| SPC | Summary of Product Characteristics (UK) |
| USAN | United States Adopted Name |
Pulvinal Beclometasone may be available in the countries listed below.
UK matches:
Beclometasone 17α,21-dipropionate (a derivative of Beclometasone) is reported as an ingredient of Pulvinal Beclometasone in the following countries:
International Drug Name Search
Glossary
| SPC | Summary of Product Characteristics (UK) |
Meylon may be available in the countries listed below.
Sodium Bicarbonate is reported as an ingredient of Meylon in the following countries:
International Drug Name Search
Bonviva may be available in the countries listed below.
UK matches:
Ibandronic Acid is reported as an ingredient of Bonviva in the following countries:
Ibandronic Acid sodium salt monohydrate (a derivative of Ibandronic Acid) is reported as an ingredient of Bonviva in the following countries:
International Drug Name Search
Glossary
| SPC | Summary of Product Characteristics (UK) |
Bevantolol Hydrochloride may be available in the countries listed below.
Bevantolol Hydrochloride (BANM, USAN) is also known as Bevantolol (Rec.INN)
International Drug Name Search
Glossary
| BANM | British Approved Name (Modified) |
| Rec.INN | Recommended International Nonproprietary Name (World Health Organization) |
| USAN | United States Adopted Name |
Esomac may be available in the countries listed below.
Esomeprazole is reported as an ingredient of Esomac in the following countries:
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Apodorm may be available in the countries listed below.
Nitrazepam is reported as an ingredient of Apodorm in the following countries:
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Calcium Sandoz Junior may be available in the countries listed below.
Calcium Carbonate is reported as an ingredient of Calcium Sandoz Junior in the following countries:
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Loratadine is reported as an ingredient of Children's Claritin in the following countries:
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Myrosone may be available in the countries listed below.
Neomycin sulfate (a derivative of Neomycin) is reported as an ingredient of Myrosone in the following countries:
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Amlodipin Arcana may be available in the countries listed below.
Amlodipine maleate (a derivative of Amlodipine) is reported as an ingredient of Amlodipin Arcana in the following countries:
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Picyn may be available in the countries listed below.
Sultamicillin is reported as an ingredient of Picyn in the following countries:
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Flemagon may be available in the countries listed below.
Carbocisteine is reported as an ingredient of Flemagon in the following countries:
Sobrerol is reported as an ingredient of Flemagon in the following countries:
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Lusyton may be available in the countries listed below.
Amantadine hydrochloride (a derivative of Amantadine) is reported as an ingredient of Lusyton in the following countries:
International Drug Name Search
In the US, Propine (dipivefrin ophthalmic) is a member of the drug class ophthalmic glaucoma agents and is used to treat Glaucoma - Open Angle and Intraocular Hypertension.
US matches:
UK matches:
Dipivefrine hydrochloride (a derivative of Dipivefrine) is reported as an ingredient of Propine in the following countries:
International Drug Name Search
Glossary
| SPC | Summary of Product Characteristics (UK) |
Riboflavine Ratiopharm may be available in the countries listed below.
Riboflavin is reported as an ingredient of Riboflavine Ratiopharm in the following countries:
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Loxin may be available in the countries listed below.
Levofloxacin is reported as an ingredient of Loxin in the following countries:
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Ranox may be available in the countries listed below.
In some countries, this medicine may only be approved for veterinary use.
Rafoxanide is reported as an ingredient of Ranox in the following countries:
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Phylobid may be available in the countries listed below.
Theophylline is reported as an ingredient of Phylobid in the following countries:
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Chloortalidon Actavis may be available in the countries listed below.
Chlortalidone is reported as an ingredient of Chloortalidon Actavis in the following countries:
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In the US, Atrovent Nasal (ipratropium nasal) is a member of the drug class nasal antihistamines and decongestants and is used to treat Rhinorrhea.
US matches:
Ipratropium Bromide is reported as an ingredient of Atrovent Nasal in the following countries:
Ipratropium Bromide monohydrate (a derivative of Ipratropium Bromide) is reported as an ingredient of Atrovent Nasal in the following countries:
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Tanvimil E may be available in the countries listed below.
Tocopherol, α- acetate (a derivative of Tocopherol, α-) is reported as an ingredient of Tanvimil E in the following countries:
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Candilin may be available in the countries listed below.
Fluconazole is reported as an ingredient of Candilin in the following countries:
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Praticef may be available in the countries listed below.
Cefonicid disodium salt (a derivative of Cefonicid) is reported as an ingredient of Praticef in the following countries:
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Bronsidal may be available in the countries listed below.
Salbutamol is reported as an ingredient of Bronsidal in the following countries:
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Hypadil Kowa may be available in the countries listed below.
Nipradilol is reported as an ingredient of Hypadil Kowa in the following countries:
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Lazid may be available in the countries listed below.
Gliclazide is reported as an ingredient of Lazid in the following countries:
Lamivudine is reported as an ingredient of Lazid in the following countries:
Stavudine is reported as an ingredient of Lazid in the following countries:
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Captopril Fariberica may be available in the countries listed below.
Captopril is reported as an ingredient of Captopril Fariberica in the following countries:
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Crotétamide may be available in the countries listed below.
Crotétamide (DCF) is also known as Crotetamide (Rec.INN)
International Drug Name Search
Glossary
| DCF | Dénomination Commune Française |
| Rec.INN | Recommended International Nonproprietary Name (World Health Organization) |
Aisoskin may be available in the countries listed below.
Isotretinoin is reported as an ingredient of Aisoskin in the following countries:
International Drug Name Search
Mofur may be available in the countries listed below.
Mometasone 17-(2-furoate) (a derivative of Mometasone) is reported as an ingredient of Mofur in the following countries:
International Drug Name Search
Cenipres may be available in the countries listed below.
Enalapril maleate (a derivative of Enalapril) is reported as an ingredient of Cenipres in the following countries:
Nitrendipine is reported as an ingredient of Cenipres in the following countries:
International Drug Name Search
Ladinin may be available in the countries listed below.
Ciprofloxacin is reported as an ingredient of Ladinin in the following countries:
Ciprofloxacin hydrochloride (a derivative of Ciprofloxacin) is reported as an ingredient of Ladinin in the following countries:
Ciprofloxacin lactate (a derivative of Ciprofloxacin) is reported as an ingredient of Ladinin in the following countries:
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Amoxicillina Alter may be available in the countries listed below.
Amoxicillin trihydrate (a derivative of Amoxicillin) is reported as an ingredient of Amoxicillina Alter in the following countries:
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Munil may be available in the countries listed below.
Bromhexine hydrochloride (a derivative of Bromhexine) is reported as an ingredient of Munil in the following countries:
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Ridaq may be available in the countries listed below.
Hydrochlorothiazide is reported as an ingredient of Ridaq in the following countries:
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Rec.INN
N05BA14
0052463-83-9
C18-H13-Cl-N2-O
308
Anxiolytic agent
Benzodiazepine derivative
Hypnotic agent
2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-phenyl-1-(2-propynyl)-
International Drug Name Search
Glossary
| DCIT | Denominazione Comune Italiana |
| IS | Inofficial Synonym |
| OS | Official Synonym |
| Rec.INN | Recommended International Nonproprietary Name (World Health Organization) |
Xymelin may be available in the countries listed below.
Xylometazoline hydrochloride (a derivative of Xylometazoline) is reported as an ingredient of Xymelin in the following countries:
International Drug Name Search
Momen may be available in the countries listed below.
Naproxen sodium salt (a derivative of Naproxen) is reported as an ingredient of Momen in the following countries:
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Paradis may be available in the countries listed below.
Clindamycin is reported as an ingredient of Paradis in the following countries:
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Potasion may be available in the countries listed below.
Potassium Chloride is reported as an ingredient of Potasion in the following countries:
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Glopisine may be available in the countries listed below.
Finasteride is reported as an ingredient of Glopisine in the following countries:
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Kamillosan Chamomile Ointment
Each tube or sachet of Kamillosan Ointment contains 10.5% extracts of chamomile standardised to give 0.01% L- α-bisabolol active ingredient.
Light brown ointment with Characteristic odour.
For prophylaxis and treatment of uncomplicated inflammation of the skin including sore nipples, nappy chafe, nappy rash and chapped hands.
Kamillosan ointment is for topical application as follows:
Sore nipples in nursing mothers: after breast feeding.
Nappy chafe and nappy rash: at change of nappy.
Other conditions: twice daily as necessary.
None known
None known
None known
Kamillosan may be used during pregnancy and lactation.
None.
None known.
There are no known symptoms of overdosage.
The chamomile extract possesses topical anti-inflammatory properties due to the presence of the natural anti-inflammatory substance £-α-bisabolol.
Not applicable
There is none applicable
Beeswax BP, Emulsifying wax BP, anhydrous lanolin BP, yellow soft paraffin BP, maize oil and mixed esters of p-hydroxybenzoic acid (preservative)
None known
2 years
Store in a dry place below 25oC.
Aluminium tubes containing 5, 20, 24, 30, 50, 100 and 125g of ointment.
Sachets containing 1 and 1.5g of ointment
None.
Goldshield Pharmaceuticals ltd.
NLA Tower
12-16 Addiscombe Road
Croydon
Surrey
CR0 0XT
United Kingdom
PL 12762/0039
01ST October 1999
December 2009
In the US, Astemizole (astemizole systemic) is a member of the drug class antihistamines and is used to treat Allergic Urticaria, Allergies and Urticaria.
US matches:
Rec.INN
R06AX11
0068844-77-9
C28-H31-F-N4-O
458
Antiallergic agent
Antihistaminic agent
1H-Benzimidazole-2-amine, 1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-
International Drug Name Search
Glossary
| BAN | British Approved Name |
| DCF | Dénomination Commune Française |
| IS | Inofficial Synonym |
| OS | Official Synonym |
| PH | Pharmacopoeia Name |
| Rec.INN | Recommended International Nonproprietary Name (World Health Organization) |
| USAN | United States Adopted Name |
Buserecur may be available in the countries listed below.
Buserelin acetate (a derivative of Buserelin) is reported as an ingredient of Buserecur in the following countries:
International Drug Name Search
C-Tamin may be available in the countries listed below.
Ascorbic Acid is reported as an ingredient of C-Tamin in the following countries:
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Helmiben may be available in the countries listed below.
Praziquantel is reported as an ingredient of Helmiben in the following countries:
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Kefnir may be available in the countries listed below.
Cefdinir is reported as an ingredient of Kefnir in the following countries:
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Prosertin may be available in the countries listed below.
Sertraline hydrochloride (a derivative of Sertraline) is reported as an ingredient of Prosertin in the following countries:
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Improntal Topico may be available in the countries listed below.
Piroxicam is reported as an ingredient of Improntal Topico in the following countries:
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Clarinese Syrup may be available in the countries listed below.
Loratadine is reported as an ingredient of Clarinese Syrup in the following countries:
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Rasilez HCT may be available in the countries listed below.
Aliskiren hemifumarate (a derivative of Aliskiren) is reported as an ingredient of Rasilez HCT in the following countries:
Hydrochlorothiazide is reported as an ingredient of Rasilez HCT in the following countries:
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Fluvoxamine maleate Synthon may be available in the countries listed below.
Fluvoxamine maleate (a derivative of Fluvoxamine) is reported as an ingredient of Fluvoxamine maleate Synthon in the following countries:
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Platemeel may be available in the countries listed below.
Cilostazol is reported as an ingredient of Platemeel in the following countries:
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Konakion MM.
Each Konakion MM Ampoule contains 10.0mg vitamin K1 (phytomenadione) Ph. Eur in 1ml.
Amber glass ampoules containing 10mg phytomenadione in 1ml. The ampoule solution is clear to slightly opalescent, pale yellow in colour and contains the active constituent in a mixed micelles vehicle of glycocholic acid and lecithin.
Konakion MM is indicated as an antidote to anticoagulant drugs of the coumarin type in the treatment of haemorrhage or threatened haemorrhage, associated with a low blood level of prothrombin or factor VII.
Adults: As an antidote to anticoagulant drugs
For potentially fatal and severe haemorrhages: Konakion MM therapy should be accompanied by a more immediate effective treatment such as transfusions of whole blood or blood clotting factors. The anticoagulant should be withdrawn and an intravenous injection of Konakion MM given slowly in a dose of 10 – 20mg. The prothrombin level should be estimated three hours later and, if the response has been inadequate, the dose should be repeated. Not more than 40mg of Konakion MM should be given intravenously in 24 hours. Coagulation profiles must be monitored on a daily basis until these have returned to acceptable levels; in severe cases more frequent monitoring is necessary and where there is no immediate efficacy, transfusion of whole blood or blood clotting factors should be used.
Less severe haemorrhage: Oral treatment with Konakion tablets may be used.
Elderly
Elderly patients tend to be more sensitive to reversal of anticoagulation with Konakion MM; dosage in this group should be at the lower end of the ranges recommended.
Instructions for infusion in adults
Konakion MM Ampoules are for intravenous injection and should be diluted with 55ml of 5% glucose before slowly infusing the product. The solution should be freshly prepared and protected from light. Konakion MM Ampoule solution should not be diluted or mixed with other injectables, but may be injected into the lower part of an infusion apparatus.
Children aged 1 to 18 years
It is advisable that a haematologist is consulted about appropriate investigation and treatment in any child in whom Konakion MM is being considered.
Likely indications for using vitamin K in children are limited and may include:
1. Children with disorders that interfere with absorption of vitamin K (chronic diarrhoea, cystic fibrosis, biliary atresia, hepatitis, coeliac disease).
2. Children with poor nutrition who are receiving broad spectrum antibiotics.
3. Liver disease.
4. Patients receiving anticoagulant therapy with warfarin in whom the INR is increased outside the therapeutic range and therefore are at risk of, or are bleeding, and those with an INR in the therapeutic range who are bleeding.
For patients on warfarin therapy, therapeutic intervention must take into consideration the reason for the child being on warfarin and whether or not anticoagulant therapy has to be continued (e.g. in a child with mechanical heart valve or repeated thromboembolic complications) as vitamin K administration is likely to interfere with anticoagulation with warfarin for 2 – 3 weeks.
It should be noted that the earliest effect seen with vitamin K treatment is at 4 – 6 hours and therefore in patients with severe haemorrhage replacement with coagulation factors may be indicated (discuss with haematologist).
Dose of vitamin K
There are few data available regarding use of Konakion MM in children over 1 year. There have been no dose ranging studies in children with haemorrhage. Suggested dosages based on clinical experience are as follows:
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Prothrombin levels should be measured 2 to 6 hours later and if the response has not been adequate, the dose may be repeated. Frequent monitoring of vitamin K dependent clotting factors is essential in these patients.
Children on warfarin therapy who need to remain anticoagulated are not included in the above dosage recommendations.
Neonates and babies
Konakion MM Paediatric should be used in these patients. (See separate prescribing information.)
Use in patients with a known hypersensitivity to any of the constituents.
When treating patients with severely impaired liver function, it should be borne in mind that one Konakion MM Ampoule 10mg/1ml contains 54.6mg glycocholic acid and this may have a bilirubin displacing effect.
At the time of use, the ampoule contents should be clear. Following incorrect storage, the contents may become turbid or present a phase-separation. In this case the ampoule must no longer be used.
In potentially fatal and severe haemorrhage due to overdosage of coumarin anticoagulants, intravenous injections of Konakion MM must be administered slowly and not more than 40mg should be given during a period of 24 hours. Konakion MM therapy should be accompanied by a more immediate effective treatment such as transfusion of whole blood or blood clotting factors. When patients with prosthetic heart valves are given transfusions for the treatment of severe or potentially fatal haemorrhages, fresh frozen plasma should be used.
Large doses of Konakion MM (more than 40mg per day) should be avoided if it is intended to continue with anticoagulant therapy because there is no experience with doses above this maximum of 40mg per day and higher doses may give rise to unexpected adverse events. Clinical studies have shown a sufficient decrease in the prothrombin time with the recommended dosage. If haemorrhage is severe, a transfusion of fresh whole blood may be necessary whilst awaiting the effect of the vitamin K1.
Vitamin K1 is not an antidote to heparin.
No significant interactions are known other than antagonism of coumarin anticoagulants.
There is no specific evidence regarding the safety of Konakion MM in pregnancy but, as with most drugs, the administration during pregnancy should only occur if the benefits outweigh the risks.
None.
There are only few unconfirmed reports of the occurrence of possible anaphylactoid reactions after intravenous injection of Konakion MM. Very rarely, venous irritation or phlebitis has been reported in association with intravenous administration of Konakion mixed micelle solution. Injection site reactions have been reported after intramuscular injection of Konakion.
Hypervitaminosis of vitamin K1 is unknown.
Konakion MM is a synthetic preparation of vitamin K. The presence of vitamin K (i.e. vitamin K or substances with vitamin K activity) is essential for the formation within the body of prothrombin, factor VII, factor IX and factor X. Lack of vitamin K leads to an increased tendency to haemorrhage. When an antidote to an anticoagulant is necessary it is essential to use vitamin K1 itself, as vitamin K analogues are much less effective.
In the mixed micelles solution, vitamin K1 is solubilised by means of a physiological colloidal system, also found in the human body, consisting of lecithin and bile acid. Owing to the absence of organic solvents, the Konakion mixed micelles solution is well tolerated on intravenous administration.
In blood plasma, 90% of vitamin K1 is bound to lipoproteins. Following an intramuscular dose of 10mg vitamin K, plasma concentrations of 10 – 20mcg/l are produced (normal range 0.4 – 1.2mcg/l). Systemic availability following intramuscular administration is about 50% and elimination half-life in plasma is approximately 1.5 – 3 hours.
None applicable.
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None.
The recommended shelf-life of Konakion MM Ampoules is 36 months.
The recommended maximum storage temperature is 25°C. Do not use if the solution is turbid.
Konakion MM is supplied in amber glass ampoules containing 10mg phytomenadione in 1ml. The ampoule solution is clear to slightly opalescent, pale yellow in colour and contains the active constituent in a mixed micelles vehicle of glycocholic acid and lecithin.
See section 4.2.
Roche Products Limited, 6 Falcon Way, Shire Park, Welwyn Garden City, AL7 1TW, United Kingdom.
PL 0031/0254
April 2008
April 2008
POM
Konakion is a registered trade mark
Item Code
Pamid may be available in the countries listed below.
Indapamide is reported as an ingredient of Pamid in the following countries:
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Actan may be available in the countries listed below.
Fluoxetine is reported as an ingredient of Actan in the following countries:
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Lincoln Lice Control Plus may be available in the countries listed below.
In some countries, this medicine may only be approved for veterinary use.
Permethrin is reported as an ingredient of Lincoln Lice Control Plus in the following countries:
International Drug Name Search
Clotrix may be available in the countries listed below.
Clotrimazole is reported as an ingredient of Clotrix in the following countries:
International Drug Name Search
Genamox may be available in the countries listed below.
Amoxicillin trihydrate (a derivative of Amoxicillin) is reported as an ingredient of Genamox in the following countries:
International Drug Name Search
Alizine may be available in the countries listed below.
In some countries, this medicine may only be approved for veterinary use.
Aglepristone is reported as an ingredient of Alizine in the following countries:
International Drug Name Search
Fexazol may be available in the countries listed below.
Ketoconazole is reported as an ingredient of Fexazol in the following countries:
International Drug Name Search
Amoxicilina Sandoz may be available in the countries listed below.
Amoxicillin is reported as an ingredient of Amoxicilina Sandoz in the following countries:
Amoxicillin trihydrate (a derivative of Amoxicillin) is reported as an ingredient of Amoxicilina Sandoz in the following countries:
International Drug Name Search
In the US, Levocetirizine (levocetirizine systemic) is a member of the drug class antihistamines and is used to treat Allergies, Hay Fever and Urticaria.
US matches:
Rec.INN
R06AE,R06AE09
0130018-77-8
C21-H25-Cl-N2-O3
388
Histamine, H₁-receptor antagonist
Acetic acid, [2-[4-[(R)-p-Chloro-alpha-phenylbenzyl]-1-piperazinyl]ethoxy]-
International Drug Name Search
Glossary
| BAN | British Approved Name |
| IS | Inofficial Synonym |
| OS | Official Synonym |
| Rec.INN | Recommended International Nonproprietary Name (World Health Organization) |
| USAN | United States Adopted Name |
